OverviewErythema multiforme is a skin reaction that results in red, target-shaped patches on the skin.
What is going on in the body?Erythema multiforme is an hypersensitivity reaction commonly caused by an infection or a medication. The person's body responds to an organism or chemical with an exaggerated allergic response.
Erythema multiforme can be minor or more severe. The more severe form is also known as Stevens-Johnson syndrome. Severe reactions can involve the skin, lungs, kidneys, eyes, and other areas. Rarely, an exceptionally severe case may be fatal.
What are the signs and symptoms of the condition?Signs and symptoms of erythema multiforme include the following:
• reddish-purple, target-shaped patches on the skin, especially the palms and soles
• hive-like, raised swollen areas on the skin that do not clear up like true hives
• open, tender areas of the surfaces of the mouth, eyes, and genitals
• general discomfort
• fatigue
• fever
Severe cases may cause skin peeling and serious eye inflammation, among other signs and symptoms.
What are the causes and risks of the condition?
Erythema multiforme is an exaggerated allergic reaction that may be triggered by the following: medications, such as some drugs used to treat diabetes, seizures, and tuberculosis, as well as nonsteroidal anti-inflammatory drugs (NSAIDs), some antibiotics, and barbituratesinfections with viruses, such as herpes simplex, hepatitis A, hepatitis B, measles, mumps, chickenpox, or poliomyelitis infections with bacteria, such as tularemia, tuberculosis, gonorrhea, or certain types of pneumoniafungal infections, such as histoplasmosiscancer, such as leukemia, a type of blood cancerpregnancyradiation therapy
What can be done to prevent the condition?
Prevention of erythema multiforme is only possible when the cause is known. If it is caused by a medication, the medication may need to be stopped. Medications used to treat herpes, such as acyclovir or valacyclovir, may prevent recurrence if the condition is caused by a herpes outbreak. Most cases are not preventable.
How is the condition diagnosed?
Erythema multiforme is usually diagnosed by its appearance. In some cases, a skin biopsy
may be needed. This involves taking a small piece of skin with a special tool. This piece can then be analyzed under a microscope to make the diagnosis.
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