sleep and dreams center
Fight Fatigue

printer friendly version
“ The military has a high-stake interest in this new drug. Wartime missions often require sleep deprivation of pilots. ”
Modafinil: The Ultimate Wake-up Pill? (cont'd)
small text
large text
The military has a high-stake interest in this new drug. Wartime missions often require sleep deprivation of pilots. Vietnam War aircrews were the first to widely use amphetamines. More recently, the Air Force gave Dexedrine to most flight crews during the Persian Gulf War. More than 60 percent of those who used it said it had been "essential" to accomplishing their mission.

Beyond the military, there is huge mainstream potential for a drug that would keep people awake and alert without significant side effects. Shift workers and those looking to take on another job or expand their hours of productivity could benefit.

"It can keep you more alert, but whether it can keep you at full mental performance remains to be seen," says Scammell. "Can a surgeon still operate with the same precision?"

Although modafinil has inspired much research, relatively little is actually known about how it works. "The fundamental mechanism remains obscure," says Scammell.

Brain cells, also known as neurons, rely on neurotransmitters like dopamine, to communicate with each other. One neuron releases a neurotransmitter, which relays a message to the next one. The brain's neurons serve many distinct functions. Some are involved in making you fall asleep, while others wake you up. One thing that scientists have learned in recent years is that the systems that put you to sleep probably do so by shutting off the ones that promote wakefulness and vice versa.

Dopamine plays an important role in one of the wake-promoting pathways in the brain. One of the primary ways amphetamines keep people awake is by blocking protein structures known as transporters from reabsorbing the neurotransmitters back into the cells that released them.

One of the ways in which modafinil works could be similar, affecting the neurotransmitter dopamine, Scammell says. One study, conducted by him and his colleagues, found the drug activated rat brain neurons that normally respond to dopamine. A different study by Stanford researchers reported that rats that lacked a reuptake transporter for dopamine did not respond to modafinil.

Because modafinil seems like such a great fix to a sleepy problem, Scammell says he worries that people with real medical reasons for their sleepiness, such as sleep apnea, will take the medication instead of getting a proper evaluation by their doctors. And ultimately, there's nothing like the real thing. "As best as I'm aware, if you're really sleep-deprived, it doesn't matter how many stimulants you give somebody," he says. "There's no substitute for sleep."


previous
1 . 2
 

Pictures: DCI |

SUBSCRIBE TO OUR NEWSLETTERS

Discovery Channel | TLC | Animal Planet | Discovery Health | Science Channel | Planet Green
Discovery Kids | Military Channel | Investigation Discovery | HD Theater | Turbo | FitTV

HowStuffWorks | TreeHugger | Petfinder | PetVideo | Discovery Education

Visit the Discovery Store: Toys & Games | Telescopes | DVD Sets | Planet Earth DVD | Gift Ideas

By visiting this site, you agree to the terms and conditions
of our Visitor Agreement. Please read. Privacy Policy.
ATTENTION! We recently updated our privacy policy. The changes are effective as of September 10, 2008.
To see the new policy, click here. Questions? See the policy for the contact information.

Copyright © 2009 Discovery Communications, LLC.

The leading global real-world media and entertainment company.

 
Advertisement

Sponsored Links
newsletter