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Ancient Egyptian goddess Isis, who cured the head pain of the god Ra.
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Mother-Goddess Isis Cures
The oldest medical manuscript, the Ebers Papyrus, discovered at Thebes, Egypt, and dating between 1534 and 3000 BCE, has 12 prescriptions for headache and describes several different types of headache. Migraine was considered separately and was treated with the fish Siluris (an electric cat fish).

One headache preparation was prepared by the revered mother-goddess Isis herself for the sun god Ra:

The manuscript says: "A sixth remedy that Isis made for Ra himself to eliminate the disease that is in his head: fruit of coriander…made into a mass, honey is mixed with it, the head is bandaged therewith so that it goes immediately well with him."

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